摘要
实验用同种异体犬长骨骨髓脂肪静脉注射法产生脂肪栓塞综合征的实验模型。对照组单纯注射骨髓脂肪，而用药组在注射骨髓脂肪的同时注射丹参注射液。检测动脉血氧分压、游离脂肪酸、血栓素／前列腺环素、超氧化物歧化酶／丙二醛、血凝块冰冻切片等，结合眼球结膜微循环观察、￣（９９ｍ）锝肺扫描等方法，来探讨丹参注射液防治脂肪栓塞综合征的作用及机制。实验表明：￣（９９ｍ）锝肺核素扫描对脂肪栓塞综合征的早期诊断有一定的作用；脂肪栓塞综合征除了游离脂肪酸的毒性作用外，还存在氧自由基损伤；丹参注射液对实验性脂肪栓塞综合征有一定的防治作用。
AbstractThis study was to examine the effects and mecha-nisms of injection salviae miItiorrhizae(ISM)in prevent-ing and treating fat embolism syndrome(FES),whichwas simulated by intravenous injection of honiologousbone marrow fat in 16 dogs. PaO_2,free fatty acids(FFAs),TXA_2/PGI_2,SOD/MDA were measured indifferent times combined with X-ray,conjunctiva mi-crocirculation observation,radioisotope scanning andhistologic examination.It was found that in the controlgroup there were a significant fall in PaO_a and rise inFFAs and MDA;blood clot stained with oil red Oshowed many fat droplets;radioisotope scanning re-vealed mild hypoperfusion or perfusion defects.In thetreatment group,arterial oxygen levels were main-tained,serum level of FFA_s and MDA was reduced sig-nificantly.It is concluded that there is damage inducedby oxygen-derived radicals in FES,LSM is an effectivetherapy for the FES,and￣(99m) Tc radioisotope scanning isa promising technique for noninvasive identification ofFES in the early stage.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1994年第11期692-695,T122,共5页
Chinese Journal of Surgery
