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调节性T细胞的研究进展 被引量：2

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摘要 调节性T细胞对于维持机体免疫自稳、防止自身免疫病具有极其重要的作用,也涉及抗感染免疫、肿瘤免疫、移植免疫、变态反应等许多病理性免疫过程。CD4+CD25+调节性T细胞是调节性T细胞中最为重要的一群,此外,Tr1,Th3等细胞也归属于调节性T细胞。调节性T细胞是外周免疫耐受的新的重要机制,它可通过细胞接触或者抑制性细胞因子作用于抗原呈递细胞或效应性T细胞,从而发挥调节作用。
作者 王艳 胡劲松 王一理 司履生
机构地区 [ 西安交通大学生命科学与技术学院癌症研究所
出处 《国外医学（免疫学分册）》 CAS 2005年第4期243-246,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 调节性T细胞 免疫耐受 CD4^+ CD25^+调节性T细胞
分类号 R392 [医药卫生—免疫学]
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参考文献16

  • 1Jordan MS, Boesteanu A, Reed AJ, et al. Thymic selection of CD4^+ CD25^+ regulatory T cells induced by an agonist self-peptide[J]. Nature Immunol,2001,2(4):301-306.
  • 2Ethan MS. Regulatory T cells in Autoimmunity[J]. Annu Rev Immunol,2000,18:423-449.
  • 3Malek TR, Yu A, Vincek V, et al. CIM regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2[J]. Immunity,2002,17(2):167-178.
  • 4Boden E,Tang Q, Bour-Jordan H, et al. The role of CD28 and CTLA4 in the function and homeostasis of CD4^+ CD25^+ regulatory T cells[J]. Novartis Found Syrup, 2003,252: 55-63.
  • 5Fontonot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells [J]. Nat Immunol, 2003,4:330-336.
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同被引文献66

  • 1张志,赵宏坤,崔治中.DNA疫苗及其安全性[J].中国预防兽医学报,2000,22(S1):232-234. 被引量：7
  • 2唐巍然,游雪甫,蒋建东.免疫T细胞在变态反应中的研究进展[J].国外医学（药学分册）,2005,32(2):97-102. 被引量：6
  • 3Herrick CA,Bottomly K.To respond or not to respond:T cells in allergic asthma.Nat Rev Immunol,2003,3(5):405-412.
  • 4Gor DO,Rose NR,Greenspan NS.Th1-Th2:a Procrustean paradigm.Nat Immunol,2003,4(6):503-505.
  • 5Kitani A,Fuss I,Nakamura K,et al.Transforming growth factor (TGF)-b1-producing regulatory T cells induce smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-b1-mediated fibrosis.J Exp Med,2003,198(8):1179-1188.
  • 6Walker MR,Kasprowicz DJ,Gersuk VH,et al.Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells.J Clin Invest,2003,112(9):1437-1443.
  • 7Lambrecht BN,Hammad H.Taking our breath away:dendritic cells in the pathogenesis of asthma.Nat Rev Immunol,2003,3(12):994-1003.
  • 8Baecher-Allan C,Brown JA,Freeman GJ,et al.CD4+CD25 high regulatory cells in human peripheral blood.J Immunol,2001,167(3):1245-1253.
  • 9Huehn J,Siegmund K,Lehmann JC,et al.Developmental stage,phenotype,and migration distinguish naive-and effector/memory-like CD4^+ regulatory T cells.J Exp Med,2004,199(3):303-313.
  • 10Cottrez F,Groux H.Regulation of TGF-b response during T cell activation is modulated by IL-10.J Immunol,2001,167(2):773-778.

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国外医学（免疫学分册）
2005年 第4期

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