摘要
用核糖核酸（ＲＮＡ）治疗肝炎肝硬化（慢性活动性肝炎（ＣＡＨ）伴代偿期肝硬化）６０例３个月，与辅酶Ｑ１０治疗３个月的另６０例对照。结果表明，ＲＮＡ改善血清蛋白和降ＡＬＴ的疗效明显优于辅酶Ｑ１０。部分病例于治疗前后测定血清Ⅲ型前胶原肽（ＰⅢＰ）和透明质酸（ＨＡ），ＲＮＡ组治疗后血清ＰⅢＰ和ＨＡ的含量明显下降，而辅酶Ｑ１０组变化不明显。用大鼠作光镜和电镜检查均揭示，ＲＮＡ有减轻肝细胞病变和减少胶原纤维增生的作用。临床观察与实验研究结果一致，说明ＲＮＡ有保护肝细胞和抗纤维化的作用。
randomized controlled
clinical study was carried out in 120 cases of post-hepatitic cirrhosis in com-pensative stage.
Among them 60 cases were treated with a 3-month course of intramuscular injectionof RNA or
other 60 case with co-enzyme Q10 respectively. The results showed that RNA was more
ef-fective in increasing patient’s serum albumin and decreasing serum alanine
transaminase(ALT),procol-lagen Ⅲ peptide(PⅢP)and hyaluronic acid(HA)than co-enzyme
Q10.Experiment on rats hepatic fi-brosis induced by intraperitoneal injection of
dimethylnitrosoamine(DMN)revealed that the degree ofhepatocytic necrcais and degeneration
and the q uantity of collagenesis were rather mild in the RNAtreated group as compared with
the pathological control and co- enzyme treated groups under microscop-ic examination,Such
changes had also been proved at the ultrastructural level.The result of the ani-mal trial was
consistent with the clinical observation. It is suggested that RNA might has the effects
ofprotecting hepatocytic necrosis and antihepatic fibrosis.
出处
《药物生物技术》
CAS
CSCD
1994年第1期42-46,共5页
Pharmaceutical Biotechnology
