摘要
于１９８９～１９９２年，在肿瘤化疗期间，应用放射免疫法检测肿瘤病人血浆皮质醇和醛固酮水平，结果化疗前属正常范围，化疗后均显著降低（皮质醇为６６３．４５±２４３．１７ｎｍｏｌ／Ｌ对４７４．７８±２７５．４５ｎｍｏｌ／Ｌ，Ｐ＜０．０１；醛固酮为６３８．８３±３２４．３９Ｐｍｏｌ／Ｌ对４３４．４５±３２２．４２Ｐｍｏｌ／Ｌ，Ｐ＜０．０２）。提示化疗对肾上腺皮质分泌功能具有明显的抑制作用，为化疗合用皮质激素类药物，已减轻化疗反应提供了理论依据。
We selected 30 patients with tumor in respiratory and metabolic system, they were routinely treated by chemotherapy within the experiment, the level of cortisol and aldosterone were examined by radioimmunoassay. As a result, the level of cortisol and aldosterone were reduced from 663. 45 ±243. 17nmol/L to 474. 78±275. 45nmol/L and from 638. 83±324. 39nmol/L to 434. 45±322. 42nmol/L respectively. It differ significantly (P<0. 01, P<0. 02). The results suggest that chemotherapy suppress the secretive function of adrenal cortex. We may use corticoid drugs to minimize the side effect during the chemotherapy.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1994年第4期245-246,共2页
Cancer Research on Prevention and Treatment
