摘要
Lmo2基因是LMO(LIM-only)家族的成员之一。作为一个原癌基因,Lmo2的染色体异位t(11;14)(p13;q11)或t(7;11)(q35;p13)与T细胞急性淋巴细胞白血病密切相关。LMO2是细胞中介导转录因子复合物形成的重要接头分子。现对LMO2的分子结构及其在正常和白血病细胞中的调控作用机制的差异作重点介绍。在此基础上还讨论了LMO2成为逆转录病毒介导的基因治疗X染色体连锁的严重联合免疫缺陷综合征过程中成为病毒插入靶位点的可能原因。
Lmo2, as an oncogene, is one of the members of the LMO (LIM-only) family. Its aberrant transcription and expression in T cells caused by translocation t(11; 14) (p13; q11) or t(7; 11) (q35; p13) was found to be associated closely with T cell acute lymphoblastic leukemia. LMO2 is an important molecule mediating the formation of transcription factor complex in normal hematopoietic cells. We herein reviewed the molecular structure and the likely mechanisms of LMO2 in the occurrence of leukemia caused by blocking T cell differentiation. Furthermore, the possibility for the development of LMO2-associated leukemia in patients with X-linked severe combined immunodeficiency after retroviral-mediated gene therapy was also discussed.
出处
《细胞生物学杂志》
CSCD
2005年第3期253-256,共4页
Chinese Journal of Cell Biology
基金
中国科学院"百人计划"项目部分资助(No.C2904108)
国家重点基础研究发展规划(973计划)项目资助(No.A1904139)~~
