摘要
目的探讨同个体乳腺原发癌和转移淋巴结肿瘤浸润淋巴细胞(TIL)抗瘤活性。方法从35例乳腺癌伴有腋窝淋巴结转移患者的乳腺原发癌组织及转移淋巴结组织中分离出乳腺原发癌TIL和转移淋巴结TIL,观察不同部位获得的TIL体外对不同部位乳腺癌细胞的杀伤活性。结果乳腺原发癌TIL对乳腺原发癌癌细胞与转移淋巴结TIL对转移淋巴结癌细胞均具有很高的杀伤活性[杀伤率分别为(71.31±3.11)%和(69.38±2.51)%],明显高于乳腺原发癌TIL对转移淋巴结癌细胞和转移淋巴结TIL对乳腺原发癌癌细胞的杀伤活性[杀伤率分别为(50.31±2.89)%和(49.80±3.21)%]。结论同一个体乳腺癌其原发癌和转移淋巴结TIL抗瘤活性有差别。
Objective To investigate the anti- breast cancer activity of tumor- infiltrating lymphocyte (TIL) isolated from primary breast cancer and metastatic lymphaden. Methods TILs were isolated from primary breast cancer and metastatic lymphadens of thirty- five patients with breast cancer respectively. Their killing activities of TILs on autogenous breast primary cancer cells and metastatic cancer cells in vitro were assayed. Results The killing activity isolated from primary breast cancer on breast cancer cells was very high [killing rate: (71.31±3.11) %]. The killing activity of TILs isolated from metatastic lymphaden on metastatic cancer cells was also very high [killing rate: (69.38±2.51) %]. Their killing rates were higher obviously than that of TILs isolated from primary breast cancer on metastatic cancer cell and that of TILs isolated from metastatic lymphaden on primary breast cancer cell [killing rates: (50.31±2.89) % and (49.80±3.21) %, respectively]. Conclusions The results indicated that the anti- tumor activities of TILs isolated from primary breast cancer differ from that of TILs isolated from metastatic lymphaden.
出处
《肿瘤研究与临床》
CAS
2005年第3期185-186,共2页
Cancer Research and Clinic
关键词
乳腺原发癌
转移淋巴结
肿瘤浸润淋巴细胞
杀伤活性
Primary breast cancer
Metastatic lymphaden
Tumor-infiltrating lymphocyte
Killing activity
