摘要
４８１例急性早幼粒细胞白血病经全反式维甲酸诱导达完全缓解后，分别接受４种不同的缓解后治疗方案，经随访２～８７（中位数２５）个月，从Ｋａｐｌａｎ－Ｍｅｉｅｒ生存曲线与生存概率比较，以化疗与维甲酸交替治疗组疗效较好。３年生存概率为０．７６８±０．０６２。持续单用维甲酸维持组疗效最差。
our hundred and eighty one patients of acutepromyelocytic leukemia (APL) received all-trans retinoicacid (ATRA) as remission induction therapy andachieved complete remission (CR). The patients werethen entered into four groups of different post remissiontherapy. The follow-up durations were 2 to 87 monthswith a median of 25 months. The results showed thatthe protocol of alternating administration of ATRA andchemotherapy was the best post remission therapy asdemonstrated by the kaplan-Meier survival curve andsurvival probability of the patients. The 3 year survivalprobability of this protocol was 0. 768± 0. 062. The ef-fects of using ATRA alone for post remission therapywere the worst.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第8期411-413,共3页
Chinese Journal of Hematology
关键词
维甲酸
白血病
诱导分化
治疗
Acute promyelocytic leukemia (APL)All-trans retinoic acid (ATRA)
