摘要
目的:探讨蛋白酪氨酸磷酸酶基因(PTEN)在喉鳞癌中的表达及其临床意义。方法:应用半定量RT-PCR方法检测喉癌组织中PTENmRNA的表达。结果:淋巴结转移组喉癌较正常喉组织PTENmRNA表达下降有统计学意义(P<0.05)。病理低分化与高分化相比,PTENmRNA表达差异有统计学意义(P<0.05)。结论:PTEN基因表达下降在喉鳞癌演进中起重要作用。
Objective: To detect the mRNA expression of PTEN gene in laryngeal carcinoma, and to explore its clinical significance. Methods: The mRNA expression of PTEN in 40 tumor samples and 9 normal laryngeal samples were examined with RT-PCR. Results: The mRNA expression of PTEN in the normal laryngeal tissue was higher than that in the laryngeal cancer with lymph node metastasis (P<0.05). The difference between high and low differentiation of laryngeal carcinoma was statistically significant (P<0.05). Conclusion: The decreasing of mRNA expression PTEN may be related with the lymph node metastasis and low differentiation of laryngeal squamous cell carcinoma, which suggested that the decreasing of PTEN gene expression may take important effects in the progression of laryngeal carcinoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2005年第3期238-239,共2页
Journal of China Medical University
基金
沈阳市社会发展基金资助项目(041101)
