摘要
目的:探讨蛋白激酶C(PKC)在胃癌中的表达及其与胃癌生物学行为的关系。方法:应用竞争蛋白结合法检测PKC活性。结果:胃癌组织PKC活性明显高于癌旁组织和对照组(P<0.05);胃癌组织PKC活性与淋巴结转移和浸润深度相关(P均<0.05)。结论:PKC在胃癌发生、发展和转移中发挥重要作用。
Objective: To study the expression of protein kinase C (PKC) activity in gastric carcinoma and its relationship with the biological behavior of gastric carcinoma. Methods: Activity of PKC was determined by using competitive protein binding method. Results: Activity of PKC in gastric carcinoma was significantly higher than that in normal gastric mucosa of control group and in adjacent normal mucosa to gastric carcinoma(P<0.05). The difference of PKC activity between normal gastric mucosa and adjacent normal mucosa to gastric carcinoma was not significant. The activity of PKC was related to lymph node metastasis and invasive depth(P<0.05). Conclusion: The PKC plays an important role in the genesis, development, and metastasis of gastric carcinoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2005年第3期237-237,242,共2页
Journal of China Medical University
基金
辽宁省教育厅科研基金资助项目(202013171)
关键词
胃癌
蛋白激酶C
淋巴结转移
浸润深度
gastric carcinoma
protein kinase C
lymph node metastasis
invasive depth
