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神经跨面移植及bFGF的应用治疗家兔永久性面瘫实验研究 被引量:1

Cross-facial sural nerve graft and bFGF in treatment for chronic facial paralysis in rabbits
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摘要 目的:验证单纯跨面神经移植在治疗家兔永久性面瘫中的作用。方法:取28只家兔,切除右侧面神经,制作面瘫模型。3个月后行跨面神经移植+碱性成纤维细胞生长因子(bFGF)和肌肉结合跨面神经移植+bF GF。结果:术后6个月两组颜面外形神经、肌肉恢复无差异。神经吻合处组织学观察、电生理测试两组基本恢复正常。结论:对于家兔面瘫3个月、肌肉未完全萎缩失去功能的治疗,可采取单纯跨面神经移植+bFGF的方法。 Objective: To verify the effect of cross-facial sural nerve graft in the treatment for and to find out an effective method in treating facial paralysis of middle and advanced stage.Two measures are compared and the better one is chosen. Methods: Twenty-eight rabbits were used to make model of right facial paralysis. Three months later, cross-facial sural nerve graft with basic fibroblast growth factor (bFGF) and muscle graft with bFGF were performed separately. Results: Six months later, no difference was found in the facial feature between both groups. Anastomosed points of nerves were smooth, and nouroma was not observed. Conclusion: For rabbits with chronic facial paralysis, the cross-facial nerve grafting is simple and effective.
出处 《中国医科大学学报》 CAS CSCD 北大核心 2005年第3期214-215,共2页 Journal of China Medical University
关键词 家兔 跨面 神经移植 面瘫 rabbit cross-face transplantation of nerve facial paralysis
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  • 1王炜,苗华.超长蒂节段肌瓣移植Ⅰ期治疗晚期面神经瘫痪[J].中华医学杂志,1992,72(11):680-682. 被引量:5
  • 2Mackinnon SE,Bellon AL. A surgical alogrithm for the management of facial palsy [J]. Microsurgery, 1998,9( 1 ) : 30 - 33.
  • 3Lundberg G. Nerve regeneration and repair [ J ]. A Rev Acta Orthop Stand, 1987,58(11) : 145 -169.
  • 4洪岸 李校坤 林剑.BFGF在大鼠坐骨神经损伤修复中的作用[J].中国修复与重建外科学杂志,1999,13(5):56-56.

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