摘要
用免疫酶标（ＡＰＡＡＰ）法和淋巴细胞转化试验（ＬＴ）等方法对１５例骨髓移植（ＢＭＴ）患者的免疫功能变化进行动态观察。急性白血病化疗诱导缓解后即有ＣＤ＿４￣＋细胞，ＣＤ＿４／ＣＤ＿８比值和ＬＴ值异常。强化巩固治疗后上述异常进一步加重。ＢＭＴ后早期（９０天内）淋巴细胞亚群绝对值，血清ＩｇＧ、ＩｇＡ和ＩｇＭ水平以及ＬＴ值均低于正常，而激活淋巴细胞增加。ＢＭＴ后２年仍有ＣＤ＿４￣＋细胞、ＣＤ＿４／ＣＤ＿８比值和ＯＴ试验异常。ＢＭＴ的淋巴细胞亚群的百分比和绝对值的改变不是平行的，因此，应综合地评价两者的变化。
ith immunocytochemical method (APAAP) andlymphocyte transformation test (LT) , the immunologicchanges were observed dynamically in 15 patients under-going bone marrow transplantation (BMT). The resultswere that the numbers of CD_4￣+ T cells, CD_4/CD_8 ratioand LT Ievels were subnormal after induction remission.The decrease of lymphocyte subsets in absolute num-bers, serum IgG , IgA and IgM levels and LT level wereseen early post-BMT(≤90 days) , accompanied with in-creased numbers of activated lymphocytes. After 2 yearspost-BMT, there were abnormalities in the numbers ofCD_4￣+ T cell, CD_4/CD_8 ratio and OT test. The changesin relative and absolute numbers of lymphocyte subsetsshould be comprehensively evaluated for both changeswere asychronous post-BMT.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第4期189-191,共3页
Chinese Journal of Hematology
关键词
骨髓移植
白血病
淋巴细胞亚群
Bone marrow transplantation Acuteleukemia Lymphocyte subsetsImmnologic function
