摘要
作者应用同位素标记的微球技术检测实验性门静脉部分结扎肝前型门静脉高压症（ＰＶＬ）大鼠全身、内脏血液动力学变化和门体分流情况，ＰＶＬ大鼠门静脉压力增高（１．７５±０．２４ｖｓ．１．２３±０．１３ｋＰａ；Ｐ＜０．００１），大量门－体分流（９３％），门静脉血流量增加５０％，内脏血管阻力下降４０％，心脏指数增高５０％，末稍血管阻力下降４０％，门静脉阻力未见明显升高。说明肝前型门静脉高压症门静脉压力持续增高的主要因素是高动力的门静脉灌流，直接支持“前向性血流”观点。长期门静脉高压可产生高度的门林分流，内脏血管扩张可能是内脏高动力循环的发生因素，全身血液动力学改变继发于内脏高动力循环。
AbstractThe splanchnic and systemic hemodynamics weremeasured by radioactive microsphere techniques in aPVL rat’s model with portal hypertension.The por- tal-hypertensive rats(1.75±0. 24 vs。1. 23±0. 13 kPa,P<0. 001 ) with greater than 93% portal-systemicshunting had an increase in portal venous inflow by50%(8. 97±0. 8 vs.6. 03±0. 28ml. min￣(-1).100gBW￣(-1);P<0. 001)and a concomitant decrease by 40% in splanchnic arteriolar resistance (0. 27 ± 0. 05vs. 0. 42±0. 05kPa·ml￣(-1)·min￣(-1)·100gBW￣(-1); P<0. 01) compared with control rats. Cardiac index (54.6±4.4vs.36.5±3. 0ml· min￣(-1)· 100gBW￣(-1)) was ele-vated by 50%(P< 0. 001),and total peripheral resis-tance ( 0.052±0.006 vs.O.084±0.009kPa. ml￣(-1)·min￣(-1) . 100gBW￣(-1) ) was decreased by 40%(P<0.001). The resistance to portal blood flow in portalvein-stenotic rats(0. 087±0.011kPa . ml￣(-1) .min￣(-1))was sim11ar to that in control rats(0.076±0.01kPa·ml￣(-1)·min￣(-1)),indicating that the hyperdynamic portalvenous inflow, not resistance, was the mainstay of theelevated portal venous pressure。 Which is in favor ofthe forward flow theory of portal hypertension, Thesystemic hemodynamic parameters were secondary tothe splanchnic hemodynamic changes.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1994年第9期573-575,共3页
Chinese Journal of Surgery
