摘要
对４０例重型颅脑伤病人伤后７天内脑脊液钙调素（ＣａＭ）及乳酸含量检测，探讨二者的变化与继发性脑损害的关系及尼莫地平（Ｎｉｍｏｄｉｐｉｎｅ，Ｎｉｍ）治疗作用。结果：ＣａＭ及乳酸含量在伤后２４小时内迅速增高，分别为正常值的８．１１及２．８６倍（Ｐ＜０．０１）；以后逐渐下降，伤后７天，ＣａＭ值仍高于正常值（Ｐ＜０．０１），乳酸含量恢复正常（Ｐ＞０．０５）。伤后２４小时内，脑挫裂伤或合并血肿者ＣａＭ及乳酸含量高于硬脑膜外血肿者的相应值。Ｎｉｍ治疗后，ＣａＭ值在伤后第３天开始降低，至７天恢复正常（Ｐ＞０．０５）；乳酸含量在伤后３天复常（Ｐ＞０．０５）；疗效优于未用Ｎｉｍ治疗者。
Abstract Correlation of secondary brain injury with calmodulin
(CaM)and lactic acid levels within7 days following severe head injury were stud-ied in 40 ca es.
It was showed that CaM con-tents increased within 7 days,and reachedpeak value within 24
hours after injury。Lacticacid contents also increased and reached peakvalue within 24 hours
post injury , but becamenormal on the 7th day after injury,Those withbrain contusion had higher
CaM or lactic acidthan patients with extradural haematoma。Af-ter the use of
nimodipine(Nim),CaM contentsbegan to decrease on the third day,andreached normal value on
the 7th day after in-jury, moreover,lactic acid contents reachednormal value on the third day
after injury。Inaddition,Nim treated patients had better clini-cal results。It was suggested
Ca2+overloadwithin neuronus and energy failure play piv-otal role in the development of
secondary brain injury, and Nim has great potential in thetreatment of head injury。
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1994年第2期114-115,共2页
Chinese Journal of Experimental Surgery
