摘要
利用落体撞击大鼠脑损伤模型,在致伤后不同时间测定脑组织水含量,脑皮质和血中总钙与钙调素(CaM)含量。脑损伤后6小时,脑白质水含量已有明显增加(P<0.01),脑皮质和血中总钙、CaM 含量亦有相应的不同程度升高,至伤后48小时达峰值,伤后1周恢复接近于对照值。实验结果提示,脑损伤后脑内钙积聚和CaM含量升高是脑水肿的发生与发展重要因素之一。
The authors studied the the relationship betweentraumatic brain edema and Ca^(2+). camodulin(CaM)in 70 rats. The contents of brain water in greyand white matters were determined by drying-weighing method in survival of 6. 24. 48. 72. and168hrs (n=10. each group) respectively. Ca^2. CaMin brain cortex and blood were measured at differenttimes. It were increased 6 hrs after brain injurysignificantly (P 0.01). The levels of Ca^2. CaMin brain cortex and blood elevated at earlystages. and reached its peaks 48hrs after braininjury. The preliminary results suggest thataccumulation of Ca^2 and augmentation of CaMin the brain might be one of most importantcauses in relation to traumatic brain edema.
出处
《中华神经外科杂志》
CSCD
北大核心
1992年第2期105-107,共3页
Chinese Journal of Neurosurgery
