摘要
对２０例ＩＤＤＭ患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性变化及其与红细胞内Ｎａ＋、Ｋ＋浓度、红细胞变形指数（ＥＦＩ）、空腹血糖、年龄、病程的关系进行了分析。结果表明ＩＤＤＭ患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性明显下降，且与红细胞内Ｎａ＋浓度、ＥＦＩ、病程呈负相关，而与空腹血糖、年龄无相关性。提示红细胞膜Ｎａ￣＋－Ｋ￣＋－ＡＴＰａｓｅ活性改变对红细胞变形能力有影响。
A significant defect in the Na+-K+- ATPase activities of erythrocyte
membrane of 20 IDDM patients was found as comparedwith 20 normal subjects.This defect was
accompanied by an increase in erythrocyte Na+ content and a decrease in erythrocyte
fil-terability index (EFI). So a significantly negative correlation existed between. Na+-K+-ATPase
activity and cellular Na+ content,EFI and course of the disease. A significant correlation existed
between EFI and cellular Na+content. Na+-K+-ATPase activityshowed no correlation with either
fasting blood glucose or age of the patients.These findings suggest that changes in
Na+-K+-AT-Pase activites of erythrocyte membrane exert influence on the capability of
deformation of the erythrocytes.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1994年第2期78-79,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
红细胞
糖尿病
胰岛素依赖型
Insulin-dependent diabetes mellitus Na+-K+-ATPase
Erythorcyte filterability index
