摘要
选择犬１４只，随机分为硝普钠组（ＳＮＰ组）和前列腺素Ｅ１组（ＰＧＥ１组），输注降压药使平均动脉压降低 ３０％～４０％，于降压前、降压后 １５、３０分钟及停止降压后１５分钟测定血流动力学指标。结果表明，降压期间外周血管阻力指数、肺血管阻力指数、平均肺动脉压、左室每搏功指数、右室每搏功指数两组均显著降低；ＳＮＰ组中心静脉坛显著降低，心率显著增快；ＰＧＥ１组中心静脉压、心率无显著变化。两组每搏指数、心脏指数、肺毛细血管嵌压无显著变化。
The hemodynamic effects of deliberated hypotension induced by PGE1 or SNP on 14 dogs anesthetized by ketamine were studied separately.MAP was decreased by 30%~40% after infusing PGE,or SNP Hemodynamic variables were measured before and 15 min 30 min after hypotension and 15 min after the discontinuation of infusion.The results indicated that SVRI, PVRI, MPAP, LVSWI and RVSWI all decreased significantly during PGE1-or SNP-induced hypotension. CVP decreased and HR increased significantly during SNP-induced hypotension, but with no significant change during PGE1-induced hypotension and with SVI. CI. PCWP remained unchanged in these two groups throughout the experiments.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1994年第4期278-280,共3页
Chinese Journal of Anesthesiology
关键词
前列腺素E1
控制性
降压
PGE1 Controlled hypotension Hemodynamics
