摘要
目的探索吲达帕胺与辛伐他汀联合应用对血压的影响。方法将符合条件的高血压1级患者随机分成两组。观察组:寿比山2.5mg,qd+西之达20mg,qn;对照组:寿比山2.5mg,qd。所有患者每周测血压1次,共24周。第8、24周复查血脂。结果治疗前和治疗第8周,两组的收缩压比较差异无统计学意义;治疗第16周和治疗第24周,两组的收缩压比较差异有统计学意义。两组的舒张压比较差异一直没有统计学意义。结论观察组收缩压于第16周开始与对照组比较差异有统计学意义,这可能与辛伐他汀改善血管内皮细胞的功能和大动脉的弹性有关。
[Objective]To investigate indapamide and simvastatin into treating essential hypertension. 201 cases of essential hypertension in stage one were divided into two groups-either indapamide 2.5 mg daily and simvastatin 20 mg daily night or indapamide 2.5 mg daily groups. Blood pressure was weekly measured in each case; TG or TC or HDL-C and LDL-C were measured in each case before treatment of after 8 week treatment and after 24 weeks treatment. Systolic pressure was not significantly different between the two groups (P>0.05) before treatment or after 8 week treatment, but was significantly different (P<0.05 or P<0.01) after 16 week treatment. Diastolic pressure was not significantly different between the two groups (P>0.05) from start to 24 week. [Conclusions] Systolic pressure in group eating indapamide 2.5 mg daily and simvastatin 20 mg daily night is obviously changed after 16 week treatment, the change is possibly related to simvastatin improving vascular endothelial function and elasticity of artery.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第9期1363-1364,1367,共3页
China Journal of Modern Medicine
