摘要
目的探讨CD105在胰腺癌新生血管中的表达及其临床意义。方法应用免疫组织化学SP法检测CD105标记的微血管密度(MVD)在52例胰腺癌组织和10例正常胰腺组织中的表达,分析它们与胰腺癌临床病理参数及患者生存率的关系。结果胰腺癌中MVD明显高于正常胰腺组织(P<0.01),并且MVD在高分化、中分化和低分化胰腺癌中的表达有明显差异(P<0.05);TNM分期Ⅲ～Ⅳ期、有淋巴结转移组的MVD显著高于Ⅰ～Ⅱ期、无淋巴结转移组;MVD与患者的生存率有关。结论CD105在胰腺癌新生血管中的表达为胰腺癌的诊断、恶性程度的判定、预后分析和进一步治疗提供了有效的依据。
Objective To determine the expression and clinical significance of CD105 in angiogenesis of pancreatic carcinoma. Methods The expression of MVD marked with CD105 was detected by S-P immunohistochemistry in 52 specimens of pancreatic carcinoma and 10 speimens of normal pancreas tissue. Correlation between MVD and clinicopathological features as well as survival was also statistically analyzed. Results There was a significant difference between the MVD in pancreatic carcinoma and that in the normal tissue (P<0.01). Besides, the MVD differentiated in pancreatic carcinomas with dissimilar histopathological grade(P<0.05). Furthermore, the MVD in stage from Ⅲ to Ⅳ was much higher than that in stage from Ⅰ to Ⅱ. In the same way, the MVD in those with metastasis of lymph node was much higher than those without metastasis. The analysis of single factor revealed that the MVD evidently related with the survival rate of patients. Conclusion The experiment suggests that the expression of CD105 play an important role in the estimation of diagnosis, dysplasia, prognosis and treatment of pancreatic carcinoma.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第3期463-465,共3页
Suzhou University Journal of Medical Science
