摘要
为了提高IgA肾病的临床疗效,对中药肾炎血尿康治疗IgA肾病进行了临床观察和实验研究,结果表明,肾炎血尿康治疗39例病人,总有效率为92.3％,对照组(肾炎四味片)的总有效率为57.2％,统计学处理,有显著差别(P<0.O5)。实验室检查,尿红细胞定性及尿沉渣定量治疗后较治疗前明显改善(P<0.005),尿蛋白较治疗前明显下降(P<0.005),血浆白蛋白明显提高(P<0.001),IgA较治疗前明显下降(P<0.05)。并进行了动物实验研究,结果表明,尿蛋白及尿红细胞变化与临床观察一致外,肾脏组织学变化经肾炎血尿康治疗后可见免疫荧光检查荧光强度减弱或消失,与对照组比较,P<0.05;光镜下可见基质扩张及炎细胞浸润明显减轻,电镜与光镜结果一致。由此说明,肾炎血尿康是治疗IgA肾病的有效方剂。
In order to improve the curative effects of IjjA nephrosis, we observed the disease treated with ' shenyanxueniaokang' and did experimental research. The results shown that the totally effective rate was 92. 3 percent,the controlled group was 57. 2 percent, the difference was obvious (p<0- 05)- RBC in urine and urinary sediment were improved more obviously than pretreated (p<0- 005),urinary protein was obviously lower (p<0- 005),plasma albumin was increased (p<0. 005),Content of IgA was obviously lower than pretreatmed (p<0. 05)- the results of animal experimental research shown that the changes of RBC in urine and urinary protein were harmony with clinical observation results,the changes of kind-ney histology,fluorescein strength was decreased or disappeared by immunfluoroscopy, the difference with controlled group was obvious (p<0. 05),stro-mal expanding and inflammatory infiltration relvat-ing could be observed under optical microscope, the results obsvered under electron microscope were the same as optical microscope. All these shown that ' shenyianxueniaokang' was the effective decoction to treat IgA neprosis.
出处
《中国中医药科技》
CAS
1994年第1期19-22,共4页
Chinese Journal of Traditional Medical Science and Technology
