摘要
目的探索异丙酚麻醉时人脑不同部位氨基酸递质水平的动态变化,阐明异丙酚麻醉中枢可能的作用机制。方法应用磁共振波谱分析(HMRS)技术,选取10名志愿者,首先分别在清醒状态下做MRS扫描,作为自身对照波谱;然后TCI靶控异丙酚在效应室浓度达3.0μg.ml^(-1)时进行第二次MRS扫描,采集波谱。扫描选择的感兴趣区(VOI)均为皮层运动区、皮层感觉区、丘脑、海马和基底节区。测定N-乙酰基天门冬氨酸(NAA)、谷氨酸(Glu)、γ-氨基丁酸(GABA)的动态变化。结果静脉推注异丙酚麻醉后NAA在丘脑和海马区域与清醒时比较明显降低(P<0.05);Glu在丘脑、海马和基底节区明显降低(P<0.05);GABA在皮层运动区、皮层感觉区、丘脑、海马和基底节区均显著升高(P<0.05)。结论异丙酚麻醉对中枢不同区域内NAA、Glu、GABA 氨基酸类神经递质均有影响,其中GABA可能在异丙酚的全麻机制中发挥更为重要的作用。
Objective To investigate the changes in amino acids neurotransmitter metabolism in different cerebral regions produced by propofol in volunteers . Method The levels of N - acetylaspartic acid (NAA) , glutamic acid (Glu) and γ - aminobutyric acid (GABA) in the sensory cortex,motor cortex, thalamus, hippocamus and basal ganglia before and during anesthesia with propofol (target effect concertration,3.0 μg. mL^(-1)) were determined by the proton magnetic resonance spectroscopy ( H - MRS) in 10 healthful volunteers. Results Compared with before the anesthesia ,NAA content in the thalamus and hippocampus and the Glu content in the thalamus, hippocampus and basal ganglia significantly decreased ( P < 0.05 ) , but GABA content in the sensory cortex, motor cortex, thalamus, hippocampus and basal ganglia signiflcantly incressed ( P <0. 05) during propofol anesthesia. Conclusions The inhibitory effects of propofol may be related to the changes in the neurotransmitter metabolism and GABA may playa more importance role in propofol anesthesia than NAA and Glu.
出处
《华南国防医学杂志》
CAS
2005年第2期1-3,22,共4页
Military Medical Journal of South China
基金
国家自然科学基金项目 (30271257)
