摘要
本研究动态观察了中药补肾密骨液对２３例绝经后妇女骨质丢失的预防作用，并与对照组２０例进行比较。结果显示：治疗组口服补肾密骨液５个月后，其尺、桡骨骨矿物质含量较治疗前明显增加（Ｐ均＜０．０５），而对照组却呈进行性减少。治疗组空腹尿钙、羟脯氨酸与肌酐比值较治疗前下降，且低于对照组（Ｐ均＜０．０５）；血清碱性磷酸酶含量治疗前后无显著性差异（Ｐ＞０．０５）。提示：补肾密骨液能够预防绝经后妇女的骨质丢失，其机理与其能降低骨的吸收，同时不影响成骨活动有关。
The effect of Bushen Migu Ye(BSMGY) on preventing the bone loss in postmenopausal women was observed.43 healthy women with the menopause within 5 years were randomly divided into the treated and control groups,which were basically similar in age and menopausal time.BSMGY and Rhizoma Dioscoreae decoction was given orally in two groups.Some biochemical parameters related to bone metabolism,serum estradiol and forearm bone density were taken before and after treatment.The results showed that 5 months after BSMGY treatment,the ulnar and radial bone mineral content was higher than that of pretreatmental value(P<0.05),while in control group this index was continually decreased.The change in bone density were also significant different(P<0.05).It seems that BSMGY is able to prevent the bone loss in postmenopausal women.In the treated group,ratio of fasting urinarycalcium and hydroxyproline to creatinine was lower than that of before treatment and the control group(P<0.05);the concentration of serum alkaline phosphatase had no significant difference(P>0.05).This preliminary study suggested that one of the therapeutic mechanism of BSMGY was probably due to declining of bone resorption,without affecting the bone formation in postmenopausal women.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第9期515-518,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
补肾法
预防
骨质疏松
绝经后
Kidney Invigoration,prevention,bone loss,biochemistry,postmenopause,bone density
