摘要
目的:利用超声对比剂评价局部注射无水酒精所致大鼠肝损伤的声像图改变。方法:选用200g左右成年Wistar大鼠20只,在超声监视下对大鼠肝左外叶局部注射无水酒精0.05～0.10ml,对病灶用二维超声、彩色多普勒及能量多普勒继续观察并予以记录。7天后,对病灶再次进行超声探查,通过尾静脉通道团注超声对比剂脂氟显0.05ml/200g。利用反向脉冲谐波成像模式对病灶进行观察并记录。对肝左外叶取材制作石蜡切片进行病理检查。结果:二维超声图像上不能明确显示消融的病灶范围。用CDFI和CDE检查,6/20个病例在消融前可在局部组织检测到血流信号。所有病例超声造影后均可清晰显示消融病灶。超声造影后所测病灶大小及病理实测病灶大小有良好的相关性(r=0.97),二者之间差异无显著性意义(P=0.39)。结论:二维超声、彩色多普勒和能量多普勒对无水酒精肝脏局部注射所致消融病灶的判断作用有限,注射超声对比剂后在反向脉冲谐波成像模式下可清晰显示消融病灶,可用于准确评价消融病灶的大小。
Objective:To evaluate the focal hepatic lesion in rats caused by local injection of absolute alcohol using ultrasonic contrast Medicum.Methods:Twenty adult Wistar rats weighted about 200g were injected with absolute alcohol for 0.05～0.10ml each one in the exterior left lobe of the liver under monitoring of ultrasound.The focal lesions were scanned with conventional B-mode ultrasound,color Doppler flow imaging and color Doppler energy.Seven days later, the focal lesions were studied again as before.Then,pulse inversion harmonic imaging was used to evaluate the focal lesions after bolus injection of ultrasonic contrast (0.05ml/200g) through caudal vein.The exterior left lobe of liver with focal lesion was incised and underwent pathologic examination.Results:The focal lesions couldn't be identified clearly by traditional B-mode ultrasound.6/20 of the subjects were detected blood flow signals before intrahepatic injection of absolute alcohol.In all of the subjects,the focal lesions could be defined clearly after bolus injection of the ultrasonic contrast under mode of pulse inversion harmonic imaging.There were good correlation between the size of the focal lesions measured by ultrasound under mode of pulse inversion harmonic imaging and that obtained by pathologic examination with no significant difference (P=(0.39).)Conclusion:The role of traditional B-mode ultrasound,color Doppler flow imaging and color Doppler energy is limited in identification of the focal lesions caused by local injection of absolute alcohol in liver.Ultrasonic contrast plus pulse inversion harmonic imaging could be used to assess the size of the focal lesion mentioned above.
出处
《放射学实践》
2005年第6期542-544,共3页
Radiologic Practice
基金
湖北省自然科学基金资助项目(2004ABA247)
关键词
无水酒精
超声对比剂
反向脉冲谐波成像
Absolute alcohol
Ultrasonic contrast medicum
Pulse inversion harmonic imaging
