摘要
本实验研究发现，玉米粉中存在调节柔红霉素产生菌ＳＩＰＩ－１４８２生物合成柔红霉素的因子。这种调节因子的性质可能类似于已经报道的Ｂ因子，它不仅具有恢复突变株产生柔红霉素的能力，且能明显地提高亲株ＳＩＰＩ－１４８２和另一柔红霉素产生菌ＳＩＰＩ－ＰＦ－２５的生产能力。
A mutant strain which lost its daunomycin-producing capability was isolated after UV and NTG mutagenesis and extensive screening.It was observed that the addition of corn meal to the fermentation medium of this mutant restored its ability to produce daunomycin. Also,when the parent strain was cultivated in media containing corn meal,the yield of daunomycin increased significantly. Further studies revealed the presence of a regulatory factor in corn meal which affects the daunomycin biosynthesis.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第11期481-484,共4页
Chinese Journal of Pharmaceuticals
关键词
柔红霉素
玉米粉
调节因子
daunomycin
corn meal
regulatory factor
