摘要
目的:探讨肾移植受者尿转移生长因子β1(TGFβ1)与慢性移植物肾病(CAN)的关系。方法:1999年8月～2000年12月期间进行肾移植手术157例,在术后满1年时检测尿TGFβ1,所得相对浓度为172.5～533.1pg/mg(Cr),分别选出TGFβ1浓度最高和最低的各40例患者构成组Ⅰ和组Ⅱ,进行前瞻性观察。在肾移植达3年时,比较两组肾功能有无差异,分析肾功能与术后1年时的尿TGFβ1有无相关性,对肾功能不全者作移植肾穿剌活检,明确是否为CAN。结果:在肾移植达3年时,组Ⅰ肌酐清除率(Ccr)减少了(12.8±10.6)ml/min,29.6%的患者有肾功能不全,均显著大于组Ⅱ[分别为(6.9±5.7)ml/min和9.4%];患者Ccr与术后1年时的尿TGFβ1之间有显著的相关性;肾功能不全者,移植肾在组织学上均呈CAN病理学改变。结论:TGFβ1可能在CAN的发生中起重要作用;CAN患者在肾功能异常前尿TGFβ1已显著升高,肾移植后早期检测尿TGFβ1对远期肾功能具有预测作用。
Objective:To determine the association between urine TGF-β1 level and chronic allograft nephropathy (CAN).Methods:Clinical data of 157 patients had kidney transplantation during August 1, 1999 and December 30, 2000 were analysed. Urine TGF-β1 concentration was determined one year after transplantation. The level of urine TGF-β1 relative concentration was 172.5~533.1pg/mg(Cr).40 cases with higher urine TGF-β1 concentration formed groupⅠ,and other 40 cases with lower urine TGF-β1 formed group II.Two years later, renal function, blood and urine TGF-β1 concentration were compared between the two groups. The relation between urine TGF-β1 and CAN was assessed. Biopsies were carried out in renal recipients with abnormal creatinine.Results:More cases with abnormal renal function and CAN were noted in group I than that in group II at 3 years after transplantation.Urine TGF-β1 level was higher in group I than that in group II. The difference in the two groups was significant. Biopsies all showed the characters of CAN.Conclusions:The findings suggest that urine TGF-β1 is significantly higher before renal dysfunction in patients with CAN. The level of urine TGF-β1 in early stage after renal transplantation can predict long-term renal function.
出处
《临床泌尿外科杂志》
2005年第6期342-345,共4页
Journal of Clinical Urology
关键词
移植
肾
肾病
转移生长因子
Kidney transplantation
Nephropathy
Transforming growth factor β_1
