摘要
以α-甲基丙酰乙酸乙酯为原料,经动力学去质子化后,与乙酸乙酯发生γ-酰基化反应,然后环合生成3,5,6-三甲基-4-羟基-2-吡喃酮,在回流丁酮中甲基化主要得到3,5,6-三甲基-4-甲氧基-2-吡喃酮。两步反应总收率15.2%,经IR,1H-NMR,MS分析确定了目标化合物的分子结构。
3,5,6-Trimethyl-4-hydroxy-2-pyrone was easily prepared by acylation of dianion of ethyl-2-methyl-3-oxovalerate with ethyl acetate and the cyclization by treatment with 1,4-diazabicyclo [5,4,0] undec-7-ene (DBU). Methylation of the resultant compound in refluxing acetone yields 3,5,6-trimethyl-4-methoxyl-2-pyrone predominantly. Total yield of two steps was 15.2%. Structures of the compounds are identified by IR (infrared spectrum), 1H-NMR (nuclear magnetic resonance), MS (mass spectrum).
出处
《华东理工大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2005年第2期177-179,共3页
Journal of East China University of Science and Technology
