摘要
应用间接免疫荧光法，对３５例病程不超过１６周的Ⅰ型糖尿病人测定了血清柯萨奇Ｂ病毒抗体ＩｇＭ（ＣＢＶ－ＩｇＭ）。结果发现，初发Ⅰ型糖尿病组ＣＢＶ－ＩｇＭ检出率与正常对照组无明显区别。ＣＢＶ－ＩｇＭ检出率不受地区影响，但与年龄有关，年龄小于１９岁的Ⅰ型糖尿病人ＣＢＶ－ＩｇＭ检出率高。ＣＢＶ－ＩｇＭ与胰岛细胞抗体、胰岛素自身抗体无关，是否与ＨＬＡ－ＤＲ４、Ａ９、ＤＱ３相关尚需进一步研究。提示我国初发糖尿病人发病与ＣＢＶ感染无关，遗传易感性不同、起病年龄不同、ＣＢＶ变异株不同可能解释ＣＢＶ与Ⅰ型糖尿病相关程度的差异。
B1-6 V
specific IgM were detected in 35 cases of I diabetic patients with onset of the diseaseoccurring
within 16 wceks。Relationship of CBV infection with age,geographic location ICA, IAA andHLA
antigen typing was also studied.It turned out that 17.7%of type I diabetes had a positive
findingof CBV-IgM which,however,was not significant compared with the controls。The positive
rate ofCBV-IgM was not influenced by geographic location ,but could be affected by age,The
results did notsuggest that occurrence of type I diabetes in China was associated with CBV
infetion,We speculatedthat the diversity od genetic susceptibility, age of onset and variation of
CBV might account for thedifferent degrees of correlation between CBV infection and type I
diabetes。
出处
《中国医科大学学报》
CAS
CSCD
1994年第2期130-133,141,共5页
Journal of China Medical University
