摘要
比较了ＡＴ（Ｌａｔｅｘ免疫凝聚比浊测定法）和ＲＩＡ法（放射免疫测定法）检测新鲜的随机尿样微量白蛋白（ｍＡ），并评价其临床应用价值。健康对照组ＡＴ（－）（１１例），尿白蛋白６．０±２．３ｍｇ／Ｌ糖尿病组ＡＴ（－）（６１例），１１．０±８．７ｍｇ／Ｌ；ＡＴ（＋）组（１３例），３８．１±１０．２ｍｇ／Ｌ。用ＲＩＡ法测尿帆ｍＡ，以ｍＡ３０ｍｇ／Ｌ作为分割线，ＡＴ与ＲＩＡ法的一致率为８９．２％，结果表明ＡＴ可以作为早期糖尿病肾病尿微量白蛋白监测的简便迅速的方法。
ll diabetic patients should be screened for early signs of
diabetic nephropathy ,because it is aprognostic factor in the disease,We compared the results
of AT and of radioimmunoassay(RIA )for uri-nary albumin to evaluate the clinical utility of AT
using fresh urine samples from 74 diabetic patientswithout persistent proteinuria and from 11
healthy subjects。Urinary albumin levels were 6.0±2.3mg/L in the healthy subjects, 11.0±
8.7mg/L in the AT-negative group(n=61),and 38.1±10.2mg/L inthe AT positive group(n=13).
Using a cut-off value of 30mg/L by RIA。the rate of coincidence be-tween AT and RIA was
89.2,although five subjects were false-positive by AT,and three were false-negative。These
results show thst AT may provide a useful monitor for microalbuminuria a reliableearly marker
of diabetic nephropathy。
出处
《中国医科大学学报》
CAS
CSCD
1994年第2期126-129,共4页
Journal of China Medical University
关键词
肾病
早期诊断
糖尿病性
diabetic nephropathy
albusure test(AT)
