摘要
目的:探讨高原地区慢性阻塞性肺疾病(COPD)患者气道阻塞的可逆性,并与哮喘患者对比。方法:用SpirolabⅡ全自动肺功能仪测定COPD和哮喘患者吸入盐酸特布他林气雾剂前后肺通气功能,并进行了比较。结果:①COPD组和哮喘组的基础肺通气功能无显著差异性(P>0.05);②吸药后,两组患者的肺通气功能各项指标均明显改善(P<0.01),但COPD患者的改变率显著小于哮喘组(P<0.01);COPD单纯型组各项指标均有显著改善(P均<0.05),但改善率显著小于喘息型组(P<0.01),喘息型组改善率仍显著小于哮喘组(P均<0.01);③COPD患者中有15.2%支气管舒张试验阳性,哮喘患者中93.3%支气管舒张试验阳性。结论:COPD患者气道阻塞具有一定可逆性,但可逆性程度明显低于哮喘患者。β2-受体激动剂对高原COPD患者有明显的治疗作用。
Objective: To explore the bronchial obstruction reversibility in patients with chronic obstructive pulmonary disease at high altitude, and to conduct a comparison with that in patients with asthma . Methods: The pulmonary ventilation function of patients with chronic obstructive pulmonary disease ( COPD) and with asthma before and after inhaling terbutaline inhaler was separately determined with spirolab Ⅱ spirometer, and all corresponding parameters in two groups were compared . Results:: (1) No difference of the corresponding parameters of baseline ventilation function in two groups was found. (2) The pulmonary ventilation function of patients in two groups was obviously improved after terbutaline inhaling (-P-<0. 01) , and the improvements of which in COPD patients were significantly lower than those in asthma patients (all -P-<0.01), and the improvements of which in simple form bronchitis patients were significantly lower than those in asthmatic form bronchitis patients (-P-<0.01 ). (3) Positive reaction in bronchodilatation test was found in 15.2 % COPD patients and 93.3 % asthmatic patients. Conclusion: The bronchial obstruction in patients with COPD is of certain reversibility which is lower than that in patients with asthma. β 2 -receptor excitant can result in significant effect on patients with COPD at high altitude.
出处
《西北国防医学杂志》
CAS
2005年第3期170-172,共3页
Medical Journal of National Defending Forces in Northwest China
基金
全军医药卫生科研基金资助项目(01MB014)
关键词
慢性阻塞性肺疾病
哮喘
肺功能
支气管扩张试验
高原
Chronic obstructive pulmonary disease
Asthma
Pulmonary function
Bronchodilatation test
High altitude
