摘要
在猫和豚鼠戊巴比妥钠心衰模型上比较了米利酮和哇巴因的强心作用、安全范围和心脏毒性。米利酮作用于衰竭心脏的最大有效量为１２３８±２０３μｇ·ｋｇ－１（猫）、２１０２±２１０μｇ·ｋｇ－１（豚鼠）米利酮安全范围远大于哇巴因。毒性剂量的米利酮发生主要以室性心律失常为主的心电图变化。结果表明，米利酮的强心作用可能无种族差异性，其安全性好．但也会诱发室性心律失常。
Positive inotropic effects and safety margin of milrinone had been compared with ouabain on ailing heart model in cats and guinea-pigs.The maximum effective doses of milrinone were 1228±203 μg.kg-1(cats)and 2102±210μg. kg-1(guinea-pigs)respectively.Our data indicated that milrinone was loss toxic than ouahain,its safety margin was wider, and its selectivity was better.No differences of animal species for its inotropic offect had been shown. However the worst possibility was the incidence of cardiac arrhymias in accompany with its positive inotropic and chronotropic effect.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第1期27-30,共4页
Chinese Pharmacological Bulletin
关键词
米利酮
哇巴因
强心效应
心脏毒性
milrinone
ouabain
failingheart model
inotropic effect
therapeutic margin
therapeutic index
arrhythmias
