摘要
目的 探讨替米沙坦对肾血管性高血压心肌纤维化及结缔组织生长因子(CTGF)表达的影响。方法 建立二肾一夹肾血管性高血压(2K1C- RH)大鼠模型,将实验大鼠随机分为3组:假手术组、高血压组及替米沙坦治疗组。术后4周末开始以替米沙坦3 0mg·kg-1·d-1灌胃,共8周。测量大鼠收缩压、胶原容积分数(CVF)、血管周围胶原面积(PV CA)及CTGF、转化生长因子 β1(TGF-β1)的表达。结果 与假手术组大鼠相比,高血压组的收缩压、CVF及PVCA显著增加(P <0 .0 1) ,CTGF、TGF -β1表达上调(P <0 .0 1) ;替米沙坦组与高血压组相比,心肌组织中CVF、PVCA、CTGF及TGF -β1的表达明显降低(P <0 .0 5 )。结论 替米沙坦可抑制高血压心肌纤维化,其机制可能与下调CTGF的表达有关。
Objective To investigate the effects of telmisarta n on myocardial fibrosis and connective tissue growth factor(CTGF) in renovascular hypertensive (RH) rats. Methods RH models were established in 24 rats. rats w ere randomly divided into sham group, RH group and telmisartan group. Four weeks after, rats in telmisartan group were administered telmisartan 30-mg·kg -1·d -1 for 8 weeks. Systolic blood pressure (SBP) was measured. Co llagen volume fraction (CVF), perivascular collagen area(PVCA),CTGF and TGF-2? ? expression in l eft ventri cular tissue were calculated. Results Compared with sham grou p, The SBP,CVF,PVCA,CTGF and TGF-β 1 expression increased markedly in RH group (P<0.01). Compared with the RH group, CVF,PVCA, CTGF and TGF- β 1 expression decreased in RH group (P<0.05). Conclusions Telmisartan could inhibit the development of myocardial fibrosis i n renovascular hypertensive rats. It was probably related to the decrease exp ression of cardiacal CTGF.
出处
《现代医学》
2005年第2期101-103,共3页
Modern Medical Journal
