摘要
系统观察了柯萨基Ｂ３病毒诱导员心肌炎病理过程中，ＮＫ细胞活性和表面β－内啡肽（β－ＥＰ）受体改变的关系。在感染后３～１０天，ＮＫ细胞活性升高；血浆β－ＥＰ浓度亦显著升高；ＮＫ细胞表面β－ＥＰ受体的结合容量及解离常数均下降。提示受染鼠ＮＫ细胞膜β－ＥＰ受体的变化及血浆β－ＥＰ浓度的升高，有利于增强ＮＫ细胞的活性，减少心肌组织中感染性病毒的滴度。
he relation ofβendorphin receptor
on NK cells and NK cell acvitity in cardiac injury pro-cess of Balb/c
mice with coxsackievirus B3 ind uced myocarditis was observed
serially.During 3～10 days after infection,NK cell cytolytic activity
and the plasma β-EP contents were rapidlyincreased,the binding
volume of β-EP receptor on NK cells were decreasd.Above results
sugestthat the changes of β-EP receptor on NK cells of infected mice
were benifical for enhancing NKcell activity and limiting virus
replication.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第3期155-158,共4页
Chinese Journal of Immunology
