摘要
合成并表征了新的小肽配体N -(S- 三苯甲基巯基乙酰基)丙氨酰甘氨酰甘氨酸(Tr- MAAG2 ).通过直接标记法制备了水溶性配合物99mTc -MAAG2,并对其体外稳定性进行了检测.研究了配合物99mTc- MAAG2 在荷瘤鼠体内的生物分布以及血液清除,结果表明,99mTc- MAAG2 在肿瘤和肌肉中的质量摄取率am之比为2. 67,肿瘤和血液的am之比为0.75,血液清除较快.
A new peptide ligand N-(S-tritylmercaptoacetyl)alanylglycylglycine (Tr-MAAG 2) is synthesized and characterized by IR, 1 HNMR, 13 CNMR and elemental analysis. The complex 99m Tc-MAAG 2 is prepared by directly labeling method. The partition coefficient and stability in vitro indicate that the complex is hydrophilic and stable over a period of 6 h at room temperature. The biodistribution of 99m Tc-MAAG 2 in mice bearing S180 tumor shows that the uptake ratios of tumor-to-muscle and blood at 3 hours post injection are 2.67 and 0.75, respectively, and quick blood clearance.
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第2期166-168,共3页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金资助项目(20171008
20371009)
北京师范大学青年科学基金(理科)资助项目(107197)
