摘要
１７只家兔烫伤前和烫伤后７天静脉注射庆大霉素３ｍｇ／ｋｇ（ｎ＝７）和丁胺卡那霉素１０ｍｇ／ｋｇ（ｎ＝１０）的药动学资料比较的结果表明，２０％体表面积三度烫伤后家兔的庆大霉素和丁胺卡那霉素血浓度均明显下降；两药分布容积（Ｖ＿ｄ）均增加，半衰期（ｔ＿（１／２））缩短和药时曲线下面积（ＡＵＣ）减小。本实验证实，烫伤能改变庆大霉素和丁胺卡那霉素的药动学井导致伤后两药血浓度降低。
rabbits were given Gentamicin (3mg/kg)and 10 rabbits were given Amikacin(10mg/kg)intravenously before and on 7th day after scald burns respectively,The pharmacokinetic data showed that both Ge-ntamicin and Amikacin serum levels lowered significantly in rabbits with athird degree 20%TBSA burn on 7th day postscald;the distribution vo-luine expanded,the half life shortened and the area under curve reduced in pharmacokinetic parameters of both aminoglycosides,This experiment demonstrates that the pharmacokinetics of Gentamicin and Amikacin in r-abbits can be changed after scald burns and resultant serun1 levels of bo-th aminoglycosides were decreased.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1994年第1期42-45,共4页
Chinese Journal of Antibiotics
关键词
庆大霉素
丁胺卡那霉素
药代动力学
Gentamicin
Amikacin
Pharmacokinetics
Scald burns
Rabbits
