摘要
目的:观察骨痛宁擦剂疗法对骨质疏松症患者血液流变学的影响,为骨痛宁擦剂在骨质疏松症的预防和应用方面提供理论依据。方法:选择2001-01/2003-12在四川大学华西医院康复中心就诊患者60例为研究对象。按纳入标准将60例骨质疏松症患者随机分为实验组和对照组各30例。对照组予钙尔奇D600mg,2次/d及骨友宁外擦腰背疼痛处;实验组补钙同对照组,加用骨痛宁搽剂外擦腰背疼痛处,两组均连续治疗4周。治疗前和治疗后对两组患者2周左右行血液流变学检测。结果:治疗后两组患者血液流变学大多数指标均较治疗前有所下降(P<0.05～0.01),其中对照组患者治疗后全血低切黏度、全血中切黏度、红细胞压积、全血还原低切黏度、全血还原中切黏度、血沉方程K值犤(9.52±1.62)mPa·s,(5.24±0.38)mPa·s,(40.99±2.96)%,22.24±3.56,11.09±1.20,49.92±13.71犦明显低于治疗前犤(11.00±1.69)mPa·s,(5.56±0.64)mPa·s,(43.21±3.66)%,25.29±3.42,12.89±1.85,57.14±17.71犦(P<0.05～0.01);实验组治疗后血浆高、中、低切黏度,红细胞压积,全血低、中、高还原黏度,血沉方程K值,红细胞聚集指数,红细胞电泳指数明显低于治疗前(P<0.05～0.01);实验组治疗后血液流变性的改善情况优于对照组(P<0.05)。结论:骨痛宁搽剂疗法能有效降低?
AIM: To observe the effect of Gu Tong Ning liniment on the hemorheology of patients with osteoporosis, so as to provide theoretical evidence for Gu Tong Ning liniment in the prevention and application of osteoporosis.METHODS: Sixty patients with osteoporosis,who were treated in the Rehabilitation Medicine Center, West China Hospital of Sichuan University from January 2001 to December 2003, were randomly divided into study group (n=30) and control group (n=30) according to the inclusion criterion. Patients in the control group were treated with 600 mg Caltrate D, twice a day, and the aching sites at waist and back were rubbed with Gu You Ning liniment, while patients received the same treatment except that Gu You Ning liniment was replaced by Gu Tong Ning liniment, both groups were treated for 4 weeks continuously. The hemorheological parameters were measured before and about two weeks after treatment respectively.RESULTS: Most of the hemorheological parameters after treatment were decreased as compared with those before treatment in both groups (P< 0.05 to 0.01). In the control group, whole blood low shear viscosity, whole blood middle shear viscosity, haematocrit (HCT), whole blood reducing low shear viscosity, whole blood reducing middle shear viscosity and erythrocyte sedimentation rate equation K value after treatment [(9.52± 1.62) mPa· s, (5.24± 0.38) mPa· s,(40.99± 2.96)% ,22.24± 3.56,11.09 ± 1.20, 49.92± 13.71] were obviously lower than those before treatment [(11.00± 1.69) mPa· s,(5.56± 0.64) mPa· s, (43.21± 3.66)% , 25.29± 3.42,12.89± 1.85, 57.14± 17.71] (P< 0.05 to 0.01).In the study group,the high,middle and low shear viscosities,HCT, whole blood reduced high,middle and low shear viscosities,erythrocyte sedimentation rate equation K value,erythrocyte aggregative index and erythrocyte electrophoresis index after treatment were remarkably lower than those before treatment (P< 0.05 to 0.01).The improvements of hemorheological parameters after treatment in the study group were superior to those in the control group (P< 0.05). CONCLUSION: Gu Tong Ning liniment can effectively decrease the blood viscosity of patients with osteoporosis, and improve their hemorheological parameters.
出处
《中国临床康复》
CSCD
北大核心
2005年第11期152-153,共2页
Chinese Journal of Clinical Rehabilitation
基金
四川省科技厅资助课题(00-D085)~~
