摘要
目的:研究半紧闭装置不同新鲜气体流量时可能存在的第二气体效应.方法:40例ASAⅠ～Ⅱ全麻病人随机分为高流量组和低流量组,每组各20例,高流量组又分为A、B两组,各10例,分别在新鲜气流量O24 L/min+N2O 6 L/min或O210L/min下接受0.6%异氟烷;低流量组分为C、D两组,各10例,分别在新鲜气流量O2 0.4 L/min+N2O 0.6 L/min或O21 L/min下接受1%异氟烷.用Datex气体监测仪连续监测麻醉气体吸入浓度(F,)、呼气末浓度(FA)、呼气末二氧化碳分压(PETCO2)、吸入氧浓度.观察高流量组20 min,低流量组30 min.比较高、低流量组内各相同时间点异氟烷FA/Fi.结果:高流量组内加吸N2O时,异氟烷的FA/Fi上升速率明显高于未加吸N2O组(P＜0.05),而低流量组内差异不明显(P＞0.05).结论:第二气体效应在不同的新鲜气体流量时表现不同.
Objective: To investigate whether the second gas effect exists in different fresh gas flow (FGF) anesthesia with semi-closed system. Methods: Forty patients were randomly assigned into high fresh gas flow (10L/min) group (HFGF, n=20) and low fresh gas flow (1L/min) group (LFGF, n=20). Both HFGF group and LFGF group were further divided into two groups, 10 patients in each group. In the group A, FGF was O_ 24L/min+N_ 2O 6L/min whereas in the group B was O_ 210L/min, the isoflurane dial was set in 0.6%. In the group C, FGF was O_ 20.4L/min+N_ 2O 0.6L/min whereas in the group D was O_ 21L/min, the isoflurane dial setting was rectified in order that the delivered concentration was 1%. Patients with abnormal heart, pulmonary, liver and kidney function were excluded. Demographic dates were comparable between the groups. The patients were premeditated with luminal 0.1g and atropine 0.5mg.Anesthesia was induced with propofol 2mg/kg, fentanyl 3μg/kg and succinylcholine 2mg/kg. After tracheal intubations the patients were mechanically ventilated to maintain P_ ETCO_ 2 at 4.5～5 kPa. The inspired concentration (F_ i) and alveolar concentration (F_ A) of isoflurane and N_ 2O were recorded every 30 second for 20min in HFGF or 30min in LFGF. The F_ A/F_ i of isoflurane was calculated. Results: The F_ A/F_ i of isoflurane rose faster in group A than that in group B(P<0.05). There was no significant difference in F_ A/F_ i of isoflurane between group C and D(P>0.05). Conclusion:The second gas effect was different in different FGF.
出处
《中国临床医学》
北大核心
2005年第2期315-317,共3页
Chinese Journal of Clinical Medicine
