摘要
雄性金黄地鼠６０只随机分成４组：Ｃ＿１组（对照组），Ｃ＿２组（胆固醇组），Ｓ组（胆固醇加饱和脂肪酸组）及Ｐ组（胆固醇加多不饱和脂肪酸组）。选用玉米油为多不饱和脂肪酸和猪油为饱和脂肪酸的来源，５周后进行血脂测定和肝ＬＤＬ受体分析。结果表明：在等量胆固醇条件下，和Ｃ＿２组比较，多不饱和脂肪酸可显著降低血清甘油三酯（ｔｒｉｇｌｙｃｅｒｉｄｅ，ＴＧ）、总胆固醇（ｔｏｔａｌｃｈｏｌｅｓｔｅｒｏｌ，ＴＣ）、低密度脂蛋白胆固醇（ｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎｃｈｏｌｅｓｔｅｒｏｌ，ＬＤＬ－Ｃ）和极低密度脂蛋白胆固醇（ｖｅｒｙｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎｃｈｏｌｅｓｔｅｒｏｌ，ＶＬＤＬ－Ｃ），而高密度脂蛋白胆固醇（ｈｉｇｈｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎｃｈｏｌｅｓｔｅｒｏｌ，ＨＤＬ－Ｃ）则升高，饱和脂肪酸使这几种脂质均明显升高；结合实验表明，Ｃ＿２组肝ＬＤＬ受体明显低于Ｃ＿１组，受体减少６８％，Ｓ组肝ＬＤＬ受体又明显低于Ｃ＿２组，受体减少８７％，而Ｐ组肝ＬＤＬ受体则高于Ｃ＿２组，受体增加３２％；而不同饮食对￣（１２５）Ｉ－ＬＤＬ与受体的亲和力无明显影响，提示两种脂肪酸对血脂的影响与肝ＬＤＬ受?
male Golden hamsters were divided into 4 groups,15 each:C_1 group(control),C_2 group(cholesterol),Sgroup(cholesterol plus saturated fatty acids)and Pgroup(cholesterol plus polyunsaturated fatty acids ).It was found that compared with the C_1 group,serum TG、TC、LDL-C and VLDL-C were increasd significantly in C_2 group,while the number of hepatic LDL receptors was decreased significantly. The serum TG、TC、LDL-C and VLDL-C were decreased in the P group and increased significantly in the S group as compared with the C_2group.Affinity of ￣(125)I-LDL binding with liver LDL receptor had no obvious difference in all four groups,while the number of hepatic LDL receptors was increased significantly in P group and decreased significantly in S group as compared with C_2 group.These studies demonstrated the important role of dietary fatty acids in adjusting the effect of cholesterol in regulating hepatic LDL receptor number.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第4期383-386,共4页
Chinese Journal of Pathophysiology
