摘要
本文用光化学法激发大鼠局部脑血栓形成，以组织病理学、局部脑血流量（ｒｅｇｉｏｎａｌｃｅｒｅ－ｂｒａｌｂｌｏｏｄｆｌｏｗ，ｒＣＢＦ）、皮层水含量、三磷酸腺苷（ａｄｅｎｏｓｉｎｅｔｒｉｐｈｏｓｐｈａｔｅ，ＡＴＰ）、二磷酸腺苷（ａｄｅｎｏｓｉｎｅｄｉｐｈｏｓｐｈａｔｅ，ＡＤＰ），一磷酸腺苷（ａｄｅｎｏｓｉｎｅｍｏｎｏｐｈｏｓｐｈａｔｅ，ＡＭＰ）、能量负荷（ｅｎｅｒｇｙｃｈａｒｇｅ，ＥＣ）、肌酸（ｃｒｅａｔｉｎｅ，Ｃｒ）及乳酸（ｌａｃｔａｔｅ，ＬＡ）为指标，探讨局部脑血栓形成后５天ｒＣＢＦ明显增加的可能机理。结果表明，血栓形成后局部脑组织ＡＴＰ水平进行性减少（Ｐ＜０．０１）、ＡＤＰ／ＡＴＰ及ＡＭＰ／ＡＴＰ比值明显升高（Ｐ均（０．０１），ＬＡ及脑水含量显著增加（Ｐ＜０．０１）。这些因素既是能量衰竭、无氧酵解的结果，又是缺血后脑损伤的原因。脑血栓形成后５天ｒＣＢＦ增加的机理可能与局部乳酸和腺苷增多有关。
Photochemically initiated regional thrombosis in rat brain hasbeen perfor-med. The histopathology, regional cerebral blood flow (rCBF) , brain water content, ATP,ADP,AMP, energy charge (EC), creatine (Cr) and lactate(LA) in cortex were used asindexes, The possible mechanism of rCBF increasing which occured at 5 days following cere- bral thrombosis was discussed. The results showed that ATP level in the brain decreased progressively(P<0.01),ADP/ATP and AMP/ATP ratio increased markedly (P<0.01). Brain lactate and water content in the ischemic area increasedignificantly(P<0 .01).These facts were not only the results of energy failure and anaerobic glycolysis but wasalso the cause of post-ischemic brain damage. The mechanism of increased rCBF following cerebral thrombosis might be associated with increased adenosine and lactate content.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第1期95-99,共5页
Chinese Journal of Pathophysiology
关键词
光化学
血栓形成
脑缺血
能量代谢
photochemistry
Thrombosis
Regional cerebral blood folw
Energy metabloism
Brain edema
Lactates
Adenosine
