摘要
目的 肿瘤分子生物学研究表明COX-2和nm23基因异常表达与胃癌等恶性肿瘤的发生发展密切相关,本文旨在了解它们与螺旋CT的关系。方法 用免疫组化(SP)方法检测胃癌手术切除67 例标本中上述基因的表达。结果 (1)胃癌COX-2过表达率为70.1%(47/67),且过表达与肿瘤大小、大体类型、组织学类型、淋巴结转移(LN)及临床病理分期密切相关(P<0.05)。(2)LN(-)病例的nm23 低表达率(89.2%)显著低于LN(+)病例的71.6%(P<0.05);且Ⅰ+Ⅱ期病例的nm23 低表达率(90.9%)明显高于Ⅲ+Ⅳ期病例的62.2%(P <0.05)。结论 胃癌COX-2、nm23异常表达与螺旋CT征象密切相关。
Background & Objective Tumor molecular biological studies indicated that abnormal expression of cyclooxygenase-2(COX-2)and nm23 correlate with the development of gastric carcinoma.This study was designed to investigate the relationship between expressions of COX-2 and nm23 and Spiral CT features. Methods The expressions of COX-2 and nm23 were detected by using immunohistochemical(SP)method. Results Results (1) The overexpression rate of COX-2 in gastric carcinoma was 70.1%(40/67),and the overexpression of COX-2 in gastric carcinoma was correlated to tumor size,gross morphology,histological type,lymph node metastases,and clinicopathological stage of gastric carcinoma(P<0.05). (2) The low-expression rate of nm23 in patients without lymph node metastasis(89.2%)and in stageⅠ+Ⅱ(71.6%)were much higher than those in the patients with lymph node metastasis(90.9%)and in stageⅢ+Ⅳ(62.2%)(respectively, P<0.05). Conclusion Our results suggest that abnormal expressions of COX-2 and nm23 associate with Spiral CT features.
出处
《临床医学》
CAS
2005年第4期1-3,共3页
Clinical Medicine
