摘要
目的观察胰岛素对门诊2型糖尿病(DM)患者的疗效及生活质量的影响。方法120例使用大剂量口服降糖药而血糖控制不佳的门诊2型DM患者,随机分为胰岛素治疗组(诺和灵30Rbid或+小剂量二甲双胍或阿卡波糖)和对照组(单用大剂量联合口服降糖药),每组60例,SF36健康量表调查患者主要生活质量积分,并检测治疗前后8周空腹血糖(FPG)、餐后2h血糖(PPG2h)等指标。结果治疗8周后,胰岛素治疗组FPG、PPG2h、糖化血红蛋白A1C(HbA1C)较对照组显著降低,血糖下降幅度更大,达标率明显提高,胰岛β细胞功能有恢复趋势,主要生活质量积分亦明显提高(P<0.05或P<0.001);8周内低血糖发生率却未明显上升。结论门诊使用胰岛素治疗,既可使大部分患者血糖尽快达标,又能使部分患者的β细胞功能有所恢复,且在改善生活质量的基础上不增加低血糖发生率。
Objective To observe the effects and quality of life of insulin therapy for outpatients with type 2 diabetes. Methods One hundred and twenty outpatients with type 2 diabetes who had their plasma glucose poorly controlled with high doses of oral hypoglycemic agents(OHA) were randomly divided into insulin therapy group (Novolin 30R or low doses of OHA added) and control group(high doses of OHA alone). The scales of the chief quality of life (QOF) were investigated with a Chinese version of the SF-36 questionnaire. Plasma glucose indexes before and after 8 weeks treatment were measured. AT the same time, levels of glycemic decrease and targets of glycemic control after treatment and the rate of hypoglycemia during 8 weeks were observed. Results After 8 weeks treatment, in the insulin therapy group as compared with control group, FPG, PPG 2h and HbA 1C were significantly decreased, levels of glycemic decrease was significantly increased, targets of glycemic control were dramatically satisfactory ; β cell function partly was restored slightly, the scales of the chief QOF was significantly improved(P<0.05 or P<0.001),but the rate of hypoglycemia was not significantly elevated during 8 weeks. Conclusion It is not only the level of blood glucose can be decreased rapidly and QOF be significantly improved but also beta-cell function partly be restored slightly and hypoglycemic chance not significantly elevated for the type 2 diabetes outpatients treated with insulin.
出处
《上海第二医科大学学报》
CSCD
北大核心
2005年第4期415-417,共3页
Acta Universitatis Medicinalis Secondae Shanghai
