摘要
毒物对肝脏的早期作用常表现为肝混合功能氧化酶（ＭＦＯ）的变化，咖啡因主要经肝ＭＦＯ代谢，因此测定其唾液清除率（ＳＣＬｃａ）可用于早期评价某些毒物的肝毒作用。三硝基甲笨（ＴＮＴ）、铅、黄磷接触者口服１７０ｍｇ咖啡因，８小时后收集唾液测定咖啡因含量及求出ＳＣＬｃａ，对照组（１７例）为１３４．３±５９．７ｍｌ／ｍｉｎ，ＴＮＴ接触者（３７例）为６６．５±３３．８ｍｌ／ｍｉｎ（Ｐ＜０．０１），铅接触者（３４例）为６４．１±３０．３ｍｌ／ｍｉｎ（Ｐ＜０．０１），黄磷接触者（３８例）为１４９．９±６８．７ｍｌ／ｍｉｎ。以对照组ＳＣＬｃａ９５％可信限作正常范围，三种接触者ＳＣＬｃａ的异常检出率均比ＳＧＰＴ和γ－ＧＴ的异常检出率高（Ｐ＜０．０１），凡ＳＧＰＴ和γ－ＧＴ异常者ＳＣＬｃａ大多有改变。结果表明ＳＣＬｃａ作为一种无损伤性的肝代谢功能检测方法，对ＴＮＴ、铅接触者早期肝代谢功能改变的评价有一定的意义。
The arlier response of liver to some
toxi-cants is usually the change of mixed-func-tion oxidase(MFO)
Caffiene is mainly meta-bolised by hepatic MFO, thus using caffieneas
a model drug to determine its clearancerate can act as an index for
evaluating thehepatotoxic effect. The exposurers of TNT,Pb and
phosphrus were asked to take 170mgcaffiene.Saliva was
accumulatedafter 8hours.saliva caffiene clearance rate(SCLca)was
calculated according to the concentrationof caffiene in saliva,The
SCLca was 134.3±59. 7ml/min in control; 66.5 ± 33.8ml/min inTNT
exposurer(P<0.01);64.1±30.3ml/minin Pb exposurer(P<0.01) and 149.9±
68.7ml/min in phosphorus exposurer( P>0. 05). The abnormal
rates(lower or higher than95%Confident limit of the SCLca in
control)in three groups were higher than thOse detec-ted by SGPT and
γ-GT respectively.Thus,SCLca as a non-invasive method has
somesignificance in evaluating the earlier hepatoto-xicity in TNT, Pb
and phosphorus exposurers.
出处
《职业医学》
1994年第1期12-14,共3页
China Occupational Medicine
关键词
唾液
咖啡因清除率
铅
黄磷
肝毒
caffiene clearance rate ( SC-Lca),
TNT,lead,phosphorus
