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纤溶活性与2型糖尿病及其大血管病变 被引量：3

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摘要 组织型纤溶酶原激活剂(tPA)和纤溶酶原激活物抑制剂-1(PAI-1)是纤溶系统的主要调控因子。2型糖尿病患者高血糖、高胰岛素血症、脂代谢紊乱、炎症反应、肥胖等多种因素可引起血浆tPA水平降低、PAI-1水平升高。纤溶活性的降低参与了大血管病变的发生、发展。提高纤溶活性的综合治疗将对防治糖尿病大血管并发症起一定作用。
作者 张悦 苏胜偶
机构地区 河北医科大学附属第二医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第B04期42-44,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 纤溶活性 2型糖尿病 大血管病变 高血糖 高胰岛素血症 脂代谢紊乱
分类号 R587.2 [医药卫生—内分泌]
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参考文献18

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同被引文献18

  • 1陶少平.糖尿病肾病的早期诊治进展[J].中华全科医学,2003,5(1):61-63. 被引量：11
  • 2吴国仲,吴永贵.糖尿病肾病发病炎症机制研究进展[J].国外医学（泌尿系统分册）,2005,25(3):363-367. 被引量：46
  • 3Koji Y,Kyosuke T,Tetsuhito K,et al.Aging and plasminogen activatorinhibitor-1(PAI-1)regulation:implication in the pathogenesis of throm-botic disorders in the elderly.Cardiovascular Research,2005,66(3):226-285.
  • 4Navarro JF,Mora C,Gomez M,et al.Influence of renal involvemention peripheral blood mononuclear cell expression bchaviour of tumour necrosis factor-alpha and interlcukin -6 in type 2 diabetic patients.Nephrol Dial Tmnsplant,2008,23(3):919-926.
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  • 9田润华,余云云,申黎艳,葛银林.新诊2型糖尿病患者血清相关炎症因子与HbAlc联检的临床意义[J].放射免疫学杂志,2007,20(5):430-432. 被引量：2
  • 10陈良华.降低胆固醇在冠心病防治中的作用[J].国外医学（内科学分册）,1997,24(7):291-294. 被引量：33

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国外医学（内分泌学分册）
2005年 第B04期

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