期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Galectin-3及RAGE和糖尿病视网膜病变 被引量：1

暂未订购
导出
摘要 晚期糖基化终末产物(AGEs)是糖尿病视网膜病变的主要发病机制之一。它既可与AGEs受体(RAGE)结合激活核因子κB、促进血管内皮细胞生长因子等细胞因子过度表达,引起白细胞黏附、聚集和活化、周细胞凋亡、内皮细胞活化、新生血管形成等;又可通过galectin3诱导内皮细胞分化和新生血管形成、增加血视网膜屏障通透性等,最终导致糖尿病视网膜病变。由此可见,研究RAGE在糖尿病视网膜病变中的作用机制为糖尿病视网膜病变的防治带来了新希望。
作者 张丽萍 蒋玲
机构地区 山东大学齐鲁医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第B04期34-37,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 GALECTIN-3 RAGE 糖尿病 视网膜病变 发病机制
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献14

  • 1Hudson BI, Stickland MH, Futers TS, et al. Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. Diabetes, 2001,50:1505-1511.
  • 2Wendt T, Tanji N, Guo J, et al. Glucose, glycation and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy. J Am Soc Nephrol,2003,14:1383-1395.
  • 3Schmidt AM, Yan SD, Yan SF, et al. The biology of the receptor for advanced glycation end products and its ligands. Biochem Biophys Acta,2000,1498:99-111.
  • 4Shaw SS, Schmidt AM, Banes AK, et al. S100B-RAGE-mediated augmentation of angiotensin Ⅱ-induced activation of JAK2 in vascular smooth muscle cells is dependent on PLD2. Diabetes,2003,52: 2381-2388.
  • 5Yeh CH, Sturgis L, Haidacher J, et al. Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factorκB transcriptional activation and cytokine secretion. Diabetes, 2001,50:1495-1504.
  • 6Fukushi J, Makagiansar IT, Stallcup WB. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3and α3β1 integrin. Mol Biol Ce11,2004,15:3580-3590.
  • 7Kim J, Son JW, Lee JA, et al. Methylglyoxal induces apoptosis mediated by reactive oxygen species in bovine retinal pericytes. J Korean Med Sci,2004,19:95-100.
  • 8Kaji Y, Amano S, Usui T, et al. Expression and function of receptors for advauced glycation end products in bovine corneal endothelial cells.Invest Ophthahmol Vis Sci,2003,44:521-528.
  • 9Hotta K, Funahashi T, Matsukawa Y, et al. Galectin-12, an adiposeexpressed galectin-like molecule possessing apoptosis-inducing activity.J Biol Chem,2001,276:34089-34097.
  • 10Uehara F, Ohba N, Ozawa M. Isolation and characterization of galectins in the mammalian retina. Invest Ophthalmol Vis Sci,2001,42:2164-2172.

同被引文献9

二级引证文献2

国外医学（内分泌学分册）
2005年 第B04期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部