摘要
目的 探讨腺泡状软组织肉瘤 (ASPS)的临床病理特征及鉴别诊断。方法 对 2 8例ASPS进行HE染色 ,光镜观察 ,其中 18例做组化 (PAS)和免疫组化 (SP法 )染色。结果 2 8例腺泡状软组织肉瘤中 ,男性 19例 ,女性 9例 ;年龄 2～ 5 5岁 ,平均 2 9 5岁 ;病变主要位于下肢深部骨骼肌组织内。组织学可见瘤组织呈特征性的腺泡或巢团样排列 ,胞质内可见嗜伊红颗粒及结晶体 ,PAS染色 (+)。免疫组化 :18例中 ,5例S 10 0蛋白弥漫 (+) ,3例NSE局灶 (+) ,3例Vim局灶 (+) ,desmin、SMA、EMA、Myo、actin和CK均 (- )。结论 腺泡状软组织肉瘤多见于年轻男性 ,结合临床和病理特征 。
Objective To investigate the clinical pathological features and differential diagnosis of alveolar soft part sarcoma(ASPS). Methods 28 cases of ASPS were studied using HE staining, of which 18 cases were also studied using PAS staining and immunohistochemistry (SP method). Results The patients were 19 male and 9 female, aged from 2 to 55 years old (mean 29 5 years). The lesions were mainly located in the deep skeletal muscles of the lower limbs. Histologically, the tumor showed typical alveolus and nest arrangement, there were esinophilic granules and crystals in cytoplasm of the tumor cells. 18 cases were positive for PAS staining. Immunohistochemically, 5 cases were diffusely positive for S\|100, 3 cases were spot positive for NSE and 3 cases were spot positive for vimentin, but desmin, SMA, EMA, Myo, actin and CK were all negative in all cases. Conclusion ASPS is a disease which is most commonly involved in young male. By combining with clinical and pathological features we can make a correct pathological diagnosis.
出处
《诊断病理学杂志》
CSCD
2004年第6期383-385,I100,共4页
Chinese Journal of Diagnostic Pathology
