摘要
在0.1 mol/L的B-R底液(pH=4)中,用单扫描示波极谱法可以得到一个灵敏的6 巯基嘌呤与二价铜离子配合物的导数还原峰,其峰电位为-0.40 V(vs.SCE),其二阶导数波高与6 巯基嘌呤溶液在 4×10-7~1×10-5mol/L浓度范围内呈线性关系,检测限为 3×10-8 mol/L.该法可用于药物中 6 巯基嘌呤的测定,平均回收率为98 7%.对6 MP Cu2+在汞电极上的电化学行为特别是对其吸附性能进行了探讨.
A sensitive reduction peak of 6-mercaptopurine with copper(Ⅱ) complex was found by single-sweep oscillopolarograph in 0.10 mol/L Britton-Robinson medium,The peak potential was at 0.41 V (vs.SCE), The height of second-order derivative wave was linear with the concentration of 6-mercaptopurine over the range of 4×10^(-7) to 1×10^(-5) mol/L and the detection limit is 3×10^(-8) mol/L. The method was developed for the determination of 6-mercaptopurine in medicine and the average recovery was 98.7%. The electrochemical behavious of 6-mercaptopurine with copper(Ⅱ) complex at Hg electrode and its adsorptive properties were also explored.
出处
《分析测试技术与仪器》
CAS
2005年第1期28-30,共3页
Analysis and Testing Technology and Instruments
基金
广东省教育厅自然科学研究项目0164.
关键词
6-巯嘌呤
铜
极谱法
配合物吸附波
mercaptopurine
copper(Ⅱ)
polarography
adsorptive wave of complex
