摘要
将右旋麻黄碱与扑尔敏配伍，添加骨架材料研制成复方右旋麻黄碱控释片，对其进行了体内外测定。结果表明控释片基本按零级速度释放药物，在兔体内血药浓度可维持１６ｈ，生物利用度是普通片的１．５倍。控释片在温湿条件下放置３个月含量无变化。
his paper reports the preparation of
compound pseudoephedrine controlled release tablets. Thetest has been determined in vitro and
in vivo。The dissolution of the controlled releaLse tablets was bestdescribed by zero-order
release。The plasma level in rabbits could last 16 hours and its bioavailabilitywas 1.5 times as
high as the ordinary tablets,The quality could keep stable in three months under con-stant
temperature and humidity.
关键词
盐酸右旋麻黄碱
控释片
溶出度
生物利用度
pseudoephedrine
controlled release tablets
dissolution
rate:bioavailability
