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血管内皮生长因子在宫颈癌组织中的表达及其意义 被引量：1

Expression of vascular endothelial growth factor in human cervical carcinoma and its clinical significance
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摘要 目的 :探讨血管内皮生长因子 (VEGF)的表达与宫颈癌生物学行为特征的关系。方法 :采用免疫组化法 (SP)检测 78例宫颈癌中 VEGF的表达 ,以 2 5例正常宫颈组织为对照。结果 :(1) VEGF在宫颈癌中的阳性表达率为 4 1.0 %(32 /78) ,明显高于对照组的 8.0 % (2 /2 5 ) (P<0 .0 1)。 (2 ) VEGF阳性表达率在宫颈癌临床分期≤ b期者 (18.6 % )明显低于≥ a期者 (6 8.6 % ) (P<0 .0 1) ;淋巴结无转移者 (30 .0 % )明显低于有转移者 (6 0 .7% ) (P<0 .0 5 ) ;并随病理分化程度 (高、中、低分化 )的降低 ,其阳性表达率显著升高 (P<0 .0 5 )。结论 :VEGF的表达与宫颈癌的浸润转移等生物学行为关系密切 ,在宫颈癌的发生发展过程中发挥着重要作用。 Objective:To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and the biological behavior in human cervical carcinoma. Methods: VEGF expression was examined in 78 cervical carcinomas and 25 normal cervical specimens. Results: VEGF expression was significantly higher in cervical carcinomas than that in controls (41.0% vs 8%, P<0.01). VEGF was highly expressed in stage IIa or more and those with nodal metastasis compared with in stage Ib or less and those without metastasis (P<0.01～0.05). There was a positive correlation between VEGF expression and tumor differentiation. Conclusion: VEGF expression is related to the invasive growth and metastasis of human cervical carcinoma, which plays an important role in the development and progression.
作者 蒋意忠 王祥珍
机构地区 广东省茂名市计划生育服务中心 广东医学院附属医院妇产科
出处 《广东医学院学报》 2005年第1期20-21,24,共3页 Journal of Guangdong Medical College
关键词 宫颈癌 血管内皮生长因子 预后 cervical carcinoma vascular endothelial growth factor prognosis
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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二级参考文献8

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共引文献57

同被引文献22

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广东医学院学报
2005年 第1期

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