摘要
用放射免疫测定法测人血清中的心肌肌钙蛋白Ⅰ（ＣＴｎＩ），结果：急性心肌梗死组（ＡＭＩ）ＣＴｎＩ含量明显高于正常人组（Ｐ＜０．０１），与血清肌酸激酶（ＣＫ）及其同工酶（ＣＫ一ＭＢ）呈平行升高，当ＡＭＩ后３天ＣＫ及ｃＫ—ＭＢ降至正常时，ＣＴｎＩ仍高于正常组，并可持续至ＡＭＩ后８天。骨骼肌损伤ＣＫ及ＣＫ一ＭＢ明显升高，但ＣＴｎＩ皆未高出正常值上限。在其他各种疾病组中，ＣＴｎＩ值基本同正常人组，表明ＣＴｎＩ放免测定可用于评价特异性的心肌细胞坏死，并具有高的灵敏度。
ardiac troponin I(CTnI)in human serum was determined with the radioimmunoassay.Theresults showed that the concentration of CTnI in serum of patients with acute myocardial infarction(AMI)was significantly higher than that of the normal persons and parallelly increased with the eleva- tion creatine kinase(CK)and its isoenzyme(CK MB).When the content of CK and CK MB fellto normal values after 3 days of AMI.CTnI was still higher than that of the normal group and couldlast 8 days after AMI.Though the cotent of CK and CK MB was significantly elevated in the groupof the skeletal muscle damage,the content of CTnI was not above the upper limit of the normal value.The CTnI values in the other groups of diseases were fundamentally similar to those of the group ofthe normal persons. Therefore, CTnI radioimmunoassay could be used to evaluate the specific myocar-dial celluar necrosis and had greater sensitivity:
出处
《温州医学院学报》
CAS
1994年第3期136-138,共3页
Journal of Wenzhou Medical College
关键词
肌钙蛋白I
心肌
心肌梗塞
放射免疫测定
troponin I,myocardium
myocardial infarction,acute
radioimmunoassay: creatinekinase
creatine kinase isoenzyme
