摘要
目的 了解牛磺酸对铅中毒大鼠红细胞免疫功能的影响。方法 把30只Wistar大鼠随机分为正常对照组、铅染毒对照组、治疗组,每组10只动物。对照组用蒸馏水灌胃,其余组用6 g/L醋酸铅溶液按每次60 mg/kg灌胃;染毒30 d后,治疗组动物用400 mg/kg的牛磺酸每天灌胃1次,正常对照组及铅染毒对照组用等剂量蒸馏水灌胃,连续30 d。采用酵母菌花环试验测定红细胞C3b受体花环率(RBC- C3b -RR)和红细胞免疫复合物花环率(RBC- CIC -RR)。结果 染毒对照组RBC C3b RR明显低于正常对照组(P<0 .01),其RBC- CIC- RR明显高于正常对照组(P<0 .01),治疗组的RBC- C3b- RR明显高于染毒组(P<0. 01),而其RBC CIC RR明显低于染毒组(P<0. 05)。结论 牛磺酸对铅中毒大鼠红细胞免疫功能的损伤具有明显的保护作用。
Objective To study the effect of taurine on red blood cell immunity in lead poisoning rats. Methods 30 rats were randomly divided into 3 groups: negative group, positive group and therapeutic group. The negative group was gavaged by distilled water while other groups by 6 g/L lead acetate solution 60 mg/kg qd for 30 days. Then the therapeutic group was gavaged by taurine solution 400 mg/kg qd and other groups by distilled water for 30 days. The changes in red blood cell receptor rosette rate (RBC-C3b-RR)and red blood cell immune complexes rosette rate (RBC-CIC-RR)were observed.Results The RBC-C3b-RR of positive group was significantly lower than that of the negative group (P<0.01), the RBC-CIC-RR of positive group was significantly higher than that of the negative group (P<0.01). The RBC-C3b-RR of the therapeutic group was significantly higher than that of positive group (P<0.01), the RBC-CIC-RR of the therapeutic group was significantly lower than that of positive group (P<0.05).Conclusion Taurine has obvious therapeutic effect against the injury induced by lead on red blood cell immunity of rats.
出处
《中国职业医学》
CAS
北大核心
2005年第1期29-31,共3页
China Occupational Medicine
关键词
牛磺酸
铅
中毒
红细胞免疫
Taurine
Lead
Poison
Red blood cell immunity
