摘要
研究了（９０）￣ＹＣｌ＿３，（９０）￣Ｙ－ＤＴＰＡ，（９０）￣Ｙ－ＤＯＴＡ和（９０）￣Ｙ－ＤＴＰＡ－ＩｇＧ的制备方法及其在小鼠体内的生物分布。（９０）￣ＹＣｌ＿３的主要积聚器官是骨，在其它组织代谢较快。（９０）￣Ｙ－ＤＴＰＡ和（９０）￣Ｙ－ＤＴＰＡ－ＩｇＧ在体内有较严重的（９０）￣Ｙ脱落；（９０）￣Ｙ－ＤＯＴＡ有效地改善了（９０）￣Ｙ在骨中的积聚，表明大环ＤＯＴＡ类衍生物是（９０）￣Ｙ标记单克隆抗体良好的配体。
?90)YCl_3,￣(90)Y-DTPA ￣(90)Y-DOTA and ￣(90)Y-DTPA-IgG were prepared and their biodistributions are in-vestigated. Unchelated ￣(90)Yachieves a high uptake in bone and has a rapid clearance in other tissues;There is a serious loss of ￣(90)Y in vivo from ￣(90)Y-DTPA and ￣(90)Y-DTPA- IgG;￣(90)Y-DOTA obviously re-duces the accumulation of￣(90)Yin bone. The result shows that DOTA is a prospective bifunctional chelat-ing agent for labeling MoAb with￣(90)Y.
出处
《同位素》
CAS
北大核心
1994年第2期98-102,共5页
Journal of Isotopes
关键词
标记
单克隆抗体
生物分布
镱90
radioimmunotherapy labeling monoclonal antibody biodistribution
