摘要
目的探讨幽门螺杆菌(Hp)相关性十二指肠溃疡(DU)患者Hp根除前后胃粘膜及血中促胃液素(Gas)和生长抑素(SS)含量变化的意义。方法采用放射免疫分析法测定Hp相关性DU患者42例Hp根除前后及正常对照者20例胃粘膜及血中Gas和SS含量。结果Hp相关性DU的患者胃粘膜及血中Gas的含量明显高于Hp阴性患者(粘膜:ng/g,226±65vs380±98;血清:ng/L,107±33vs50±8),而Hp根除后Gas含量则明显下降,Hp阳性者SS的含量低于Hp阴性患者(粘膜:ng/L,11±2 vs 42±8;血浆:ng/L,5.6±1.2vs10.2±2.3),Hp根除后SS含量显著升高,Hp感染时胃粘膜炎细胞浸润程度对Gas和SS的含量亦有一定影响。结论Gas和SS与Hp相关性DU密切相关,是参与DU发病的重要因素之一。
Objective Gastrin(Gas) and somatostain(SS) concents of gastric mucosa and blood in patients with HP-positive duodenal ulcear(DU) before and after successful eradication of Hp were studied. Methods Radioiomn unoassay was used in 42 patients with Hp-posvitive DU before and after successful eradication of Hp and 20 normal persons to determine the contents of Gas and SS in gastric nucosa and blood. Results Gas contents in the Hp-postive group were significantly higher than Hp-negative group(mucosa:ng/g,226±65 vs 380±98;serum:ng/L,107±33 vs 50±8)and became normal after Hp eradication. The SS contents in Hp-positive group were significantly lower than Hp-negative group(mucosa:ng/g,11±2 vs 42±8;)plasma:ng/L,5.6±1.2 vs 10.2±2.3) and became normal after of the Hp eradication. On the other hand, Gas and SS contents of the mucosa significantly altered with chronic and active inflammations. Conclusion Gas and SS are related closely to DU, and play an important role in the development of DU.
关键词
幽门螺杆菌
十二指肠溃疡
胃肠激素
生长抑素
促胃液素
duodenal nlcer/etiology
helicobacter infections
gastrin/analysis
somatostatin/analysis
gastric mucosa
radiommunoassay
